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Search Results for " bet bromodomain inhibitor "

20

Compounds

Cat No. Product Name Synonyms Targets
T2072 BET bromodomain inhibitor Epigenetic Reader Domain
BET bromodomain inhibitor is a potent BET inhibitor.
T39998 BET bromodomain inhibitor 1
BET bromodomain inhibitor 1 is an orally active, selective inhibitor of bromodomain and extra-terminal (BET) proteins. It specifically inhibits BRD4 with an IC50 of 2.6 nM. Additionally, BET bromodomain inhibitor 1 demon...
T2120 I-BET151 GSK1210151A Epigenetic Reader Domain
I-BET151 (GSK1210151A) (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
T79084 BET bromodomain inhibitor 3 Epigenetic Reader Domain
BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT. It is utilized in research related to contraception, cancer, and heart disease [1].
T62655 BET bromodomain inhibitor 2
BET bromodomain inhibitor 2 is a potent inhibitor of the BET-type bromodomain (IC50: 14.1 μM).
T6859 I-BRD9 GSK602 Epigenetic Reader Domain
I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
T8495 Alobresib Vorolanib,GS-5829 Epigenetic Reader Domain
Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.
T2442 CPI203 CPI 203,CPI-203 Epigenetic Reader Domain
CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T5362 Y06036 Epigenetic Reader Domain
Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
T17311 (+)-JQ1 PA Epigenetic Reader Domain
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
T8658 NEO2734 EP31670 Epigenetic Reader Domain , Histone Acetyltransferase
NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
T2480 Apabetalone RVX-208,RVX000222 Epigenetic Reader Domain , HIV Protease
Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
T6026 CPI-203 CPI 203,CPI203 Apoptosis , Epigenetic Reader Domain
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T6222 PFI-1 PF-6405761,PFI 1,PFI1 Apoptosis , Epigenetic Reader Domain , Autophagy
PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.
T12338 OXFBD04 Epigenetic Reader Domain
OXFBD04 is a potent and selective BRD4 inhibitor (IC50= 166 nM). OXFBD04 is a potent BET bromodomain ligand and exhibits additional modest affinity for the CREBBP bromodomain. OXFBD04 exhibits anti-cancer activity.
T6032 Birabresib OTX-015,OTX015 (MK 8628/Birabresib),MK-8628 Epigenetic Reader Domain
Birabresib (MK-8628) is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potential antineoplastic activity.
T4697 ABBV-744 ABBV744 Epigenetic Reader Domain , HIV Protease
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
T19618 (R)-(-)-JQ1 Enantiomer Epigenetic Reader Domain
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
T3504 AZD5153 6-Hydroxy-2-naphthoic acid AZD5153,AZD-5153 HNT salt Epigenetic Reader Domain
AZD5153 6-Hydroxy-2-naphthoic acid (AZD5153) is a potent triazolopyridazine-based Bromodomain (BRD4) and Extraterminal (BET) inhibitor used in cancer treatments.
T19935 XD14 Epigenetic Reader Domain
XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively).
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